After his sister is killed, Interpol agent Mature swears vengeance on Howard, the drug kingpin responsible for her death. Fortunately he is assigned to do just that, and after a chase through London, Rome, Athens, Paris, and New York, Howard falls from a crane.

Victor Mature stars in this European-based crime thriller. Mature is an FBI agent on the trail of a drug smuggling operation, following his quarry all over the Continent (with accompanying pretty pictures of Portugal, Spain, France etc.) The criminal mastermind (Trevor Howard) is something of a lunatic, who has already strangled Mature's sister to death just for the hell of it. Anita Ekberg plays Howard's luscious courier; as usual, her "acting" consists to breathing heavily in a low-cut dress. The title PICKUP ALLEY was the invention of Columbia's New York office: The film's original British title was INTERPOL.