A respected scientist (Boris Karloff) experimenting with brain wave impulses loses his beloved wife in an auto accident. Overwhelmed by grief, he attempts to record his deceased wife's brain patterns. When his experiment registers her brain activity, he frantically escalates his research. Enlisting the aide of a scheming clairvoyant, he resorts to desperate measures, even grave robbing and using the corpses as human radio tubes, to facilitate contact with his wife. As the bodies pile up and townsfolk close in, will the mad doctor finally break through to the other side?