A handsome yet sexually awkward young man becomes caught up in the dysfunctional web of a Cedar Rapids family in director Jeff Lipsky's caustic satirical drama. Jeff (Jonathan Groff) has had a crush on Mel (Portia Reiners) ever since high school, and now he's finally mustered the courage to chat her up. Unfortunately for Jeff, Mel isn't really interested in romance. Later, at a local party, Jeff hits it off with Mel's chaste, withdrawn older sister, Maura (Mamie Gummer), who proves unexpectedly responsive to his not-so-subtle advances. Though at first it may have seemed like a mere coincidence that Jeff was involved with both sisters, his motivations begin to seem suspicious when he allows himself to be seduced by their sexually frustrated mother, Vivian (Karen Young), whose bisexual husband, Martin (Reed Birney), left her for another man, but occasionally drops by for a quickie. Lately, Martin has been feeling like a failed father, but his ongoing efforts to reestablish a functional relationship with his daughters are continually iced by Maura, who makes no attempts to hide her distain for his lifestyle. Little do Jeff and Martin realize that they're currently on a collision course with one another, and once they meet head-on, nothing will ever be the same again.