David Burke (Sudeikis) is a small-time pot dealer whose clientele includes chefs and soccer moms, but no kids after all, he has his scruples. After his stash and his cash are stolen, leaving him in major debt to his supplier, Brad (Ed Helms), he must become a big-time drug smuggler by bringing Brad's latest shipment in from Mexico. One fake wife, two pretend kids and a huge, shiny RV later, the "Millers" are headed south of the border for a Fourth of July weekend that is sure to end with a bang.