The comic story of an alien, H-1449-6 (Shandling, THE LARRY SANDERS SHOW), sent to Earth to impregnate a human woman as part of a fiendish plot to conquer the Universe. Assuming the identity of Harold Anderson, he attempts to blend into human society (Phoenix, AZ to be exact) and begin his search for a mate. However, coming from a planet with no women and armed with a handful of inept pick-up lines and an automated reproductive unit (which emits a loud hum at the slightest titillation), he's rather ill equipped for the task at hand. But with the assistance of a philandering co-worker (Kinnear, AS GOOD AS IT GETS), Harold sets his sights on the beautiful, slightly flaky real-estate agent Susan Hart (Bening, AMERICAN BEAUTY), and sparks begin to fly in this hilarious battle of the sexes from the director of THE GRADUATE.