Rosanna Arquette is Roberta Glass, a bored New Jersey yuppie housewife who finds escapism from her mundane life in the New York personal ad exploits of a flighty bohemian named Susan (Madonna). When Roberta travels to the city to witness an ad-inspired meeting between Susan and her lover Jimmy, she bumps her head, loses her memory, and for all intents and purposes, becomes Susan, thanks to a case of mistaken identity. As a result, she is pursued by crooks and other shady characters through the funky East Village of the early '80's. Quinn is the confused film protectionist who stumbles into the role of Roberta/Susan's protector. Madonna, not quite a superstar when this was filmed, uses this small role to show the sort of charisma she would soon shower upon the world in larger doses. Steven Wright, Giancarlo Esposito, Richard Hell, Ann Magnuson, John Lurie, and Arto Lindsay also turn up in small roles in this screwball '80's love letter to the downtown scene.