Plane crash survivors are discovered wandering through "The Desert of Death." Grant, the pilot, regains his senses in the hospital and relates a tale of horror. A brilliant scientist, Dr. Arana, has devised a bizarre crossbreeding program to create an army of nightmarish creatures. Giant tarantulas, fiendish dwarves and beautiful, scantily-clad superwomen run amuck in his laboratory atop the Zarpa Mesa. Jackie Coogan appears as the mad scientist. Also in the fantastic cast of characters is manly Z-movie stalwart Allan Nixon (Prehistoric Women), Richard Travis (Missile To The Moon), diminutive actors John George and Angelo Rossitto, as well as Ed Wood principals Delores Fuller and Mona McKinnon. The soundtrack, which features flamenco guitar and jarring piano chords, was written by the prolific Hoyt Curtin and later used in Ed Wood's Jailbait.

A mad scientist (Jackie Coogan, "Uncle Fester" from TV's "The Addams Family") has hidden out in the deadly desert known as Zarpa Mesa in Mexico. Here he develops giant spiders, deadly dwarves, and, through the use of a synthesized derivative of spider venom, a race of killer superwomen that cannot be stopped once they choose their sexual prey. This hugely enjoyable film was made by the legendary Ron Ormond, a director whose biggest claim to fame these days is his close association with Ed Wood. However, his movies demand to be seen in their own right, as Mr. Ormond's taste for the bizarre is enough to carry a film by itself.