Circus monkey Ham III (voiced by Andy Samberg) works in a circus where he's regularly shot from a canon but he still lives in the shadow of his father's legacy (Ham I was the first chimp shot into space in 1961). A natural born rebel against authority, Ham the third is initially reluctant to go on a dangerous space mission to rescue a lost space probe, but away he goes, for lots of RIGHT STUFF-style astro-training alongside two highly prepared chimps, Luna and Titan (Cheryl Hines and Patrick Warburton). NASA's by-the-book methods jar with Ham's mischief-making of course, but once the space training ends, the mission begins, with myriad dangers along the way, including: a big-toothed monster and a run amok alien named Zartog (Jeff Daniels) whose harnessed the previous space probe for world-domination purposes, all good opportunities for Ham III to redeem himself. Despite all the fangs, parents shouldn't worry too much; not a hair on any chimp is seriously singed, and along the pratfall strewn way there's time for lessons about responsibility and realization of one's full potential. While the animation here is not quite up to Pixar level, it's still pretty and colorful, with a pleasing Candyland quality to the alien planet surface. Samberg brings a savvy zest to his vocal duties as the Ham, Stanley Tucci is a nefarious senator and--getting big laughs with flawlessly deadpan elan--Patrick Breen as one of the trio of egghead scientists. Kird De Micco directed; based on the computer video game.