Dr. Winifred Walker (Ivory Stone) and Nobel Prize-winner Dr. Stein (B-movie icon John Hart) believe they can restore dismembered Vietnam vet Eddie Turner (Joe De Sue) to the man he once was. But the results turn monstrous, and the Blackenstein Monster goes on a rampage of murder and disemboweling, unaffected by fists, bullets and blunt objects. Who or what can stop this menace? And will Dr. Stein have to return his Nobel Prize?

Eddie is a war victim who has lost all four of his limbs in Vietnam. He thinks he as found replacement parts through Dr. Stein, but the procedure accidentally turns him into a monster.