William Fitzgerald (Richard Derr), the sole survivor of a shipwrecked freighter, washes ashore onto the strange and mysterious "Blood Island." Near death, he is rescued by Dr. Charles Girard (Francis Lederer), a scientist researching the evolutionary link between man and beast. Much to the fear of the natives, Girard's bizarre experiments have successfully transformed a wild panther into human form. Hungry for blood, the tormented creature prowls the tropical jungle, intent on killing anyone in its path.

Inspired by H.G. Wells' classic novel The Island of Dr. Moreau, this spine-tingling horror classic was the first of four "Blood Island" features made in the Philippines by legendary indie filmmaker Eddie Romero.

When a shipwreck survivor washes up on the shore of a remote island, he finds himself in the company of a mad doctor who has created a bloodthirsty monster that is half panther half man.